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9.2.14

introduction about complexometric titration


Complexation reactions are widely used in analytical chemistry. 
One of the first uses of these reactions was for titrating cations, the major topic of this work.
 A complexometric titration is the one of titrimetric methods in which the reaction between 
 the analyte and titrant involves the formation of a complex.
 a successful analytical method must meet the following requirements:
(i)        the reaction must be sufficiently fast;
(ii)      it should lead stoichiometrically to a single product ML without any intermediate reactions or by-products;
(iii)    there should be a large increase in free energy (see Gibbs Energy), so that the reaction is effectively complete, that is, the stability constant; Kf must be large;
(iv)    the ligand L must be readily available and give stable standard solutions;
(v)      there must be some simple means of monitoring the course of the reaction, that is, for following changes in the concentration [M] or [ML]. 

introduction about complexometric titration

These conditions are generally met if L is the conjugate base of an aminopolycarboxylic acid such as ethylenediaminetetraacetic acid (EDTA), which is known to form very stable 1:1 complexes with a large number of metals.
 The earliest examples of metal–ligand complexation titrations are Liebig’s determinations, in the 1850s, of cyanide and chloride using, respectively, Ag+ and Hg2+ as the titrant. Practical analytical applications of com¬plexation titrimetry were developed after the introduction of amino carboxylic acids as multi-dentate ligands by Schwarzenbach in 1945.